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Among them, 6-gingerol has an obvious effect on the S phase of the proliferation cycle of human cervical cancer Hela cells (HeLa) [54]

The goat anti-rabbit Alexa Fluor 488 secondary antibody, the membrane marker wheat germ agglutinin (WGA) conjugated to Alexa Fluor 594 and 4,6-diamidino-2-phenylindole (DAPI) were obtained from Life Technologies (Carlsbad, CA, USA)

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

In animal studies, GHK-Cu accelerated wound contraction, increased granulation tissue formation, stimulated angiogenesis (new blood vessel growth), and increased antioxidant enzyme activity at wound sites

To the best of our knowledge, neither clinical trials assessing ferroptosis inhibitors in COVID-19 related PD nor any indication of the ferroptosis signature in the brain tissues of COVID-19 patients exist